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KMID : 0369319940140020246
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Allergy
1994 Volume.14 No. 2 p.246 ~ p.252
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A Case of Crohn´s disease Developed During Immunotherapy in Patient with Bronchial Asthma
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강문수
강천일/서영익/황윤근/최영환/이종명/김능수
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Abstract
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Cronhn´s diseases is an indolent, chronic inflammatory disorder capable of involving the entire alimentary tract.
The exact etiology and pathogenesis remain unknown despite a long and intensive research, but the finding of various abnormalities of the immune response in patients with Cronh´s disease has led to the concepts that immune mechanisms are involved
in the
pathogenesis of this disease.
Recently, we have experienced a case of Crohn´s disease which beveloped during immunotherapy for 7 years in a 17-year-old asthmatic patient.
Since immunotherapy results in the formation of IgG antibodies directed against the immunizing antigens, the production of circulating immune complex(CIC) consisting of IgG antibodies and antigenic components contained in the immunotherapy
extracts
theoretically could occur.
Though the over-all risk of CIC-mediated disease in patients undergoing immunotherapy is presumably extremely low, we postulate the immunotherapy could be responsible for the occurrence and/or aggravation of Crohn´s disease in this patient.
A probable causal role of immunotherapy in Crohn´s disease clearly requires further investigations.
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KEYWORD
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